CRF is a set of paper forms in which study site staff write manually relevant data from the medical chart of a clinical trial patient. Completed paper CRFs are then sent to the sponsor for double data entry into a computer. eCRF is just the electronic version of CRF allowing study site staff to encode data straight into electronic forms that can be accessed immediately by the sponsor. In other words, using eCRF prevents the paper based transcribing step.
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